Integra
The Integra Laboratory Crimper is a small vial crimper that is ideal for development, pre-clinical, clinical, pilot and compounding pharmacy operations. Available in four configurations the Integra can meet your small batch size needs assuring the best possible seal integrity.
Ensuring Seal Integrity in Stoppered Vial Systems
The Integra uses a proven three spinning roller sealing head design to crimp seals on your vial. A servo driven actuator will bring the sealing head to the vial and utilize a load cell to accurately provide proper sealing pressure. This functionality provides a quality seal despite variations in vial height.
The stoppered vial is a widely used container closure system for parenteral drug products. While this system is common, it should not be considered functionally integral until the rubber stopper has been properly compressed and secured in place. This critical step involves applying sufficient compression to the elastomeric closure and securing it with a crimped aluminum ferrule. Only then can the closure system be deemed capable of effectively preventing contamination and maintaining the sterility and stability of the drug product.
Seal integrity hinges on the precise compression of the elastomeric stopper against the vial's sealing surface. This compression must be consistently maintained by the crimped aluminum ferrule to ensure a robust and leak-proof seal. The degree of compression is determined by the force applied during the crimping process — a factor that directly affects seal performance and product reliability.
The Integra addresses this challenge by precisely controlling the crimping force applied to each vial. By managing stopper compression with accuracy, the Integra reduces variability in seal formation and promotes consistent, repeatable results across production batches.
The sealing process is straightforward and operator-friendly. The operator begins by placing a vial into the holding fixture and closing the safety guard. Upon pressing the cycle start button, the system activates an actuator that brings the sealing head assembly down onto the vial. The sealing head applies the predetermined force needed to compress the elastomeric closure. Once the target force is reached, spinning rollers engage the skirt of the aluminum cap, and the rotating sealing head executes the crimping action.
After the crimp is complete, the sealing head retracts to its home position. At this point, the Operator Interface clearly indicates that the cycle has finished and it is safe to open the safety guard and remove the sealed vial.
By automating and controlling the crimping process, the Integra enhances seal quality, reduces human error, and ensures the reliability and integrity of every sealed vial
The Integra is Available in Four Different Configurations
Single Vial Unit
The Base Model - One vial package loaded at a time by the operator. This simple and efficient design is perfect for low to medium production volumes or laboratory settings. The manual loading process allows for careful inspection of each vial while maintaining consistent crimping quality.
Compact Starwheel Unit
A 8 pocket starwheel in a compact size making it ideal for use in smaller spaces. This compact configuration features a minimal footprint while maintaining high efficiency. The starwheel indexes vials through the crimping station at a constant rate, allowing for smooth, continuous operation. Perfect for facilities that need automated vial processing within the confined spaces of isolators and laminar flow hoods.
Starwheel Unit
The Starwheel Unit features a larger 12 pocket constant indexing starwheel, designed to significantly increase throughput for higher production demands. This configuration enables the simultaneous processing of multiple vials, with each pocket securely holding a vial as it moves through the crimping station in a smooth, continuous motion.
Dual Turntable Unit
A dual turntable unit allowing for up to 200 vials to be processed at a time. This configuration is ideal for high-volume production environments where throughput is critical. The dual turntable design enables the processing of larger vial batches, significantly increasing efficiency and productivity.